I guess the obvious answer is “yes” as there is always notepad and command line compilation, but if you want to use Visual Studio or do anything with IIS, Message Queues, etc. then the answer quickly becomes a frustrating no! This hasn’t usually been a problem, but having just started in a new job which is just starting out in .NET I’m finding what a frustrating experience not having admin rights can be. Visual Studio (2008) has been installed so that’s one hurdle out of the way, but a trial install of Resharper needs admin rights, as does NUnit.
I see MS are trying to make things better with a non-admin version of IIS7 (called IIS Express) around the corner which needs VS2010 (another thing on the shopping list). But until the Visual Studio toolset can be installed using a non-admin account, it’s going to continue to be a frustrating experience!